dihydrofolic acid - PMC

Gheorghe Melinte, Andreea Cernat, Maria-Bianca Irimes, Szabolcs János Györfi, Mihaela Tertiș, Maria Suciu, Liana Anicăi, Robert Săndulescu, Cecilia Cristea

Sensors (Basel) 2020 Apr; 20(8): 2315. Published online 2020 Apr 18. doi: 10.3390/s20082315

PMCID:: PMC7219238

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Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A

Bharadwaja Vadloori, A. K. Sharath, N. Prakash Prabhu, Radheshyam Maurya

BMC Res Notes. 2018; 11: 246. Published online 2018 Apr 16. doi: 10.1186/s13104-018-3354-1

PMCID:: PMC5902840

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Amplification of protein expression in a cell free system.

E Resto, A Iida, M D Van Cleve, S M Hecht

Nucleic Acids Res. 1992 Nov 25; 20(22): 5979–5983. doi: 10.1093/nar/20.22.5979

PMCID:: PMC334463

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Analogues of folic acid and the activity of dihydrofolic acids in the synthesis of methionine by Escherichia coli

J. R. Guest, D. D. Woods

Biochem J. 1962 Jan; 82(1): 26–35. doi: 10.1042/bj0820026

PMCID:: PMC1243401

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Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Sebastian Grönke, Linda Partridge, Adam Antebi

Nat Commun. 2021; 12: 3486. Published online 2021 Jun 9. doi: 10.1038/s41467-021-23856-9

Correction in:: Nat Commun. 2021; 12: 5025.

PMCID:: PMC8190293

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Combined analysis of plasma metabolome and intestinal microbiome sequencing to explore jiashen prescription and its potential role in changing intestine–heart axis and effect on chronic heart failure

Xialian Cui, Yangyan Su, Xiaotong Huang, Jiaping Chen, Jiang Ma, Peiran Liao, Xin He

Front Cardiovasc Med. 2023; 10: 1147438. Published online 2023 Mar 10. doi: 10.3389/fcvm.2023.1147438

PMCID:: PMC10036802

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Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Amr ElShaer, Peter Hanson, Tony Worthington, Peter Lambert, Afzal R. Mohammed

Pharmaceutics. 2012 Mar; 4(1): 179–196. Published online 2012 Feb 16. doi: 10.3390/pharmaceutics4010179

PMCID:: PMC3834905

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Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii

S. F. Queener, V. Cody, J. Pace, P. Torkelson, A. Gangjee

Antimicrob Agents Chemother. 2013 Oct; 57(10): 4990–4998. doi: 10.1128/AAC.01161-13

PMCID:: PMC3811448

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Mechanistic Insights into Folic Acid-dependent Vascular Protection: Dihydrofolate reductase-mediated Reduction in Oxidant Stress in Endothelial Cells and Angiotensin II-Infused Mice: A Novel HPLC-based Fluorescent Assay for DHFR Activity

Ling Gao, Karel Chalupsky, Enrico Stefani, Hua Cai

J Mol Cell Cardiol. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: J Mol Cell Cardiol. 2009 Dec; 47(6): 752–760. Published online 2009 Aug 3. doi: 10.1016/j.yjmcc.2009.07.025

PMCID:: PMC2784291

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Cloning, Expression, and Characterization of Babesia gibsoni Dihydrofolate Reductase-Thymidylate Synthase: Inhibitory Effect of Antifolates on Its Catalytic Activity and Parasite Proliferation

Gabriel O. Aboge, Honglin Jia, Mohamad A. Terkawi, Youn-Kyoung Goo, Yoshifumi Nishikawa, Fujiko Sunaga, Kuzuhiko Namikawa, Naotoshi Tsuji, Ikuo Igarashi, Hiroshi Suzuki, Kozo Fujisaki, Xuenan Xuan

Antimicrob Agents Chemother. 2008 Nov; 52(11): 4072–4080. Published online 2008 Sep 15. doi: 10.1128/AAC.00384-08

PMCID:: PMC2573109

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

C J Allegra, J C Drake, J Jolivet, B A Chabner

Proc Natl Acad Sci U S A. 1985 Aug; 82(15): 4881–4885. doi: 10.1073/pnas.82.15.4881

PMCID:: PMC390461

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STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE

J. R. Bertino, Robert Silber, M. Freeman, A. Alenty, M. Albrecht, Beverly W. Gabrio, F. M. Huennekens

J Clin Invest. 1963 Dec; 42(12): 1899–1907. doi: 10.1172/JCI104875

PMCID:: PMC289477

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Expression of the plasmid-encoded type I dihydrofolate reductase gene in cultured mammalian cells: a novel selectable marker.

C S Simonsen, M Walter, A D Levinson

Nucleic Acids Res. 1988 Mar 25; 16(5 Pt B): 2235–2246. doi: 10.1093/nar/16.5.2235

PMCID:: PMC338212

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Select item 35908817.

Densely methylated DNA islands in mammalian chromosomal replication origins.

E S Tasheva, D J Roufa

Mol Cell Biol. 1994 Sep; 14(9): 5636–5644. doi: 10.1128/mcb.14.9.5636

PMCID:: PMC359088

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Cofactor role for 10-formyldihydrofolic acid.

J E Baggott, G L Johanning, K E Branham, C W Prince, S L Morgan, I Eto, W H Vaughn

Biochem J. 1995 Jun 15; 308(Pt 3): 1031–1036. doi: 10.1042/bj3081031

PMCID:: PMC1136826

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para-Aminobenzoic Acid Biosynthesis Is Required for Listeria monocytogenes Growth and Pathogenesis

Yingying Zhang, Andrea Anaya-Sanchez, Daniel A. Portnoy

Infect Immun. 2022 Nov; 90(11): e00207-22. Published online 2022 Nov 1. doi: 10.1128/iai.00207-22

PMCID:: PMC9670987

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Studies on dihydrofolic reductase, II. The activation of dihydrofolic reductase from chicken liver by iodine.

B T Kaufman

Proc Natl Acad Sci U S A. 1966 Aug; 56(2): 695–700. doi: 10.1073/pnas.56.2.695

PMCID:: PMC224428

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PMC Images search for dihydrofolic acid

Scheme 1

The electrochemical reversible reduction of FA to 5, 8 dihydrofolic acid [].

Selective Detection of Folic Acid Using 3D Polymeric Structures of 3-Carboxylic Polypyrrole

Sensors (Basel). 2020 Apr;20(8):2315.
Figure 1.

Molecular targets for bacteria-specific imaging agents. PTS, phosphotransferase system; DHPS, dihydropteroate synthetase; DHP, dihydrofolic acid; THF, tetrahydrofolic acid.

Radiotracer Development for Bacterial Imaging

J Med Chem. ;63(5):1964-1977.
Fig 6

(a) Plot of K_m of dihydrofolic acid (DHFA) versus K_i for OAAG324. This figure graphically summarizes the results showing that substituting amino acids from pcDHFR or pjDHFR active-site positions 35 and 64 into hDHFR primarily caused the human enzyme to become more sensitive to OAAG324. Substitutions into pcDHFR at these positions raised the K_m for DHFA and tended to lower the K_i for OAAG324. Changes induced by substitutions into pjDHFR were less dramatic than for the other two enzymes. (b) Plot of K_m of dihydrofolic acid (DHFA) versus K_i for TMP. Substituting amino acids from pcDHFR or pjDHFR active-site positions 35 and 64 into hDHFR primarily caused the human enzyme to become more sensitive to TMP. Substitutions into pcDHFR at these positions raised the K_m for DHFA and had various effects on K_i for TMP. Changes induced by substitutions into pjDHFR were less dramatic than for the other two enzymes.

Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

Antimicrob Agents Chemother. 2013 Jun;57(6):2669-2677.
FIGURE 4

Property-based alignment of dihydrofolic acid and methotrexate with BCL:MolAlign. (A) Superimposed crystallographic structures of dihydrofolic acid (DHF; PDB ID 1DHF) and methotrexate (MTX; PDB ID 1DLS) in complex with dihydrofolate reductase (DHFR). (B) Rigid alignment of DHF and MTX starting from the bioactive conformers from the crystal structures. (C) Flexible alignment of MTX (flexible) to DHF (rigid, bioactive conformer). (D) Fully flexible alignment of DHF and MTX. DHF is colored white and MTX is colored wheat. MTX was randomly rotated and translated prior to rigid alignment to DHF. All flexible alignments performed using generate_3D to remove bias from start coordinates.

Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery

Front Pharmacol. 2022;13:833099.